Archives of disease in childhood, 2011-09, Vol.96 (9), p.860-862
2011
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Childhood optic neuritis clinical features and outcome
- Ist Teil von
- Archives of disease in childhood, 2011-09, Vol.96 (9), p.860-862
- Ort / Verlag
- London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
- Erscheinungsjahr
- 2011
- Quelle
- BMJ Journals Archiv - DFG Nationallizenzen
- Beschreibungen/Notizen
- Aim To describe clinical features and outcome of a series of children with first-episode optic neuritis investigated in three paediatric neurology centres. Methods Databases were searched to identify children (<16 years) with optic neuritis and life table analysis was used. Results 44 children (female/male ratio 1.8) median age 10.9 years were followed up for median 1 year. Optic neuritis was unilateral in 43%. Maximal visual deficit was severe (<6/60) in 77%, with full recovery in 70%. Cumulative probability of developing MS (11/44) or NMO (3/44) at 2 years was 0.45. Relapsing optic neuritis was a strong predictor for development of MS or NMO. A positive MRI (>1 brain T2 hyperintense lesion) was a strong predictor for development of MS. Discussion Childhood optic neuritis is associated with severe visual deficit with good recovery. An initial abnormal MRI brain scan or relapsing optic neuritis should alert the clinician to MS or NMO diagnosis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0003-9888eISSN: 1468-2044DOI: 10.1136/adc.2009.175422Titel-ID: cdi_proquest_miscellaneous_883313123
- Format
- –
- Schlagworte
- Adolescent, Age, Anatomy, Biological and medical sciences, Brain, Care and treatment, Child, Child, Preschool, Children, Children & youth, Diseases of visual field, optic nerve, optic chiasma and optic tracts, Drug Administration Schedule, Epidemiologic Methods, Female, General aspects, Glucocorticoids - administration & dosage, Humans, Life tables, Magnetic Resonance Imaging, Male, Medical sciences, Miscellaneous, Mortality, Multiple sclerosis, Multiple Sclerosis - diagnosis, Multiple Sclerosis - etiology, Neurology, Neuromyelitis Optica - etiology, Ophthalmology, Optic neuritis, Optic Neuritis - complications, Optic Neuritis - diagnosis, Optic Neuritis - drug therapy, Optics, Patient outcomes, Patients, Pediatrics, Prevention and actions, Probability, Prognosis, Public health. Hygiene, Public health. Hygiene-occupational medicine, Recurrence, Statistical Analysis, Studies, Surveillance, Vision Disorders - etiology, Visual Acuity, Visual Impairments, Weaning