Epilepsia (Copenhagen), 2011-07, Vol.52 (7), p.e66-e69
2011
Details
- Autor(en) / Beteiligte
- Titel
- Refractory neonatal epilepsy with a de novo duplication of chromosome 2q24.2q24.3
- Ist Teil von
- Epilepsia (Copenhagen), 2011-07, Vol.52 (7), p.e66-e69
- Ort / Verlag
- Oxford, UK: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- Wiley Online Library - AutoHoldings Journals
- Beschreibungen/Notizen
- Summary There are only two reports on epileptic patients associated with microduplication of 2q. We found a de novo duplication of chromosome 2q24.2q24.3 in another infant with neonatal epilepsy. The patient had refractory focal seizures since the third day of life. Her seizures were refractory against phenobarbital and levetiracetam, but were controlled by valproate. Array comparative genomic hybridization revealed a 5.3‐Mb duplication of 2q24.2q24.3, where at least 22 genes including a cluster of voltage‐gated sodium channel genes (SCN1A, SCN2A, SCN3A, SCN7A, and SCN9A) and one noncoding RNA are located.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0013-9580eISSN: 1528-1167DOI: 10.1111/j.1528-1167.2011.03139.xTitel-ID: cdi_proquest_miscellaneous_883048375
- Format
- –
- Schlagworte
- 2q duplication, Anticonvulsants - therapeutic use, Array comparative genomic hybridization, chromosome 2, Chromosome Duplication - genetics, Chromosome Duplication - physiology, Chromosomes, Human, 1-3 - genetics, Chromosomes, Human, 1-3 - physiology, Epilepsy, Epilepsy - congenital, Epilepsy - drug therapy, Epilepsy - genetics, Etiracetam, Female, gene duplication, genomics, Humans, Infant, Newborn, Infant, Newborn, Diseases - drug therapy, Infant, Newborn, Diseases - genetics, Infants, Karyotyping, Neonatal epilepsy, Neonates, Phenobarbital, RNA, Seizures, Seizures - congenital, Seizures - genetics, Sodium channels (voltage-gated), Sodium Channels - genetics, Valproic acid, Voltage‐gated sodium channels