IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells
2011
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- Autor(en) / Beteiligte
- Titel
- IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells
- Ist Teil von
- Brain, behavior, and immunity, 2011-08, Vol.25 (6), p.1170-1181
- Ort / Verlag
- Netherlands: Elsevier Inc
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlight ► IFN-β therapy induces IL-27, which inhibits pathogenic Th17 cells that mediate autoimmunity in MS and EAE.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0889-1591eISSN: 1090-2139DOI: 10.1016/j.bbi.2011.03.007Titel-ID: cdi_proquest_miscellaneous_883045594
- Format
- –
- Schlagworte
- Adult, Allergy and Immunology, Animals, CD4+ T cell, CD4-Positive T-Lymphocytes - drug effects, CD4-Positive T-Lymphocytes - metabolism, Cells, Cultured - drug effects, Cells, Cultured - immunology, Cells, Cultured - metabolism, Dendritic cell, Dendritic Cells - drug effects, Dendritic Cells - immunology, Dendritic Cells - metabolism, Encephalomyelitis, Autoimmune, Experimental - drug therapy, Encephalomyelitis, Autoimmune, Experimental - immunology, Experimental autoimmune encephalomyelitis, Female, Gene Expression Regulation - drug effects, Humans, IFN-β, IL-27, Interferon beta-1a, Interferon beta-1b, Interferon-alpha - deficiency, Interferon-alpha - genetics, Interferon-beta - pharmacology, Interferon-beta - therapeutic use, Interleukins - antagonists & inhibitors, Interleukins - biosynthesis, Interleukins - genetics, Interleukins - physiology, Male, Mice, Mice, Inbred Strains, Middle Aged, Multiple sclerosis, Multiple Sclerosis, Relapsing-Remitting - drug therapy, Multiple Sclerosis, Relapsing-Remitting - immunology, Multiple Sclerosis, Relapsing-Remitting - physiopathology, Psychiatry, Th17, Th17 Cells - drug effects, Th17 Cells - immunology, Toll-Like Receptors - drug effects, Toll-Like Receptors - physiology, Young Adult, Zymosan - pharmacology