Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Four 4-demethoxy-3′-deamino-2′-fluoro-3′-hydroxy anthracycline analogs (
1–
4) were compared with adriamycin (doxorubicin) for their growth-inhibitory effects against five human-tumor cell lines.
Four anthracycline analogs synthesized in our laboratory were evaluated in comparison with adriamycin (doxorubicin) for their growth-inhibitory effect against five human-tumor cell lines, including lung carcinoma, colon adenocarcinoma, breast adenocarcinoma, melanoma, and glioblastoma. The compounds included 4-demethoxy-7-
O-(2,6-dideoxy-2-fluoro--
l-talopyranosyl)daunomycinone (
2), its 3′,4′-diacetate (
1), its 14-bromo derivative
3, and its 14-hydroxy analog, namely 4-demethoxy-7-
O-(2,6-dideoxy-2-fluoro-α-
l-talopyranosyl)adriamycinone (
4). Compounds
1,
2, and
3 showed moderate cytotoxic effect in most of the cell lines, while compound
4 had a strong effect, comparable to or better than that of adriamycin in most of the cell lines.