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Medical-grade silicone induces release of proinflammatory cytokines in peripheral blood mononuclear cells without activating T cells
Journal of biomedical materials research. Part B, Applied biomaterials, 2009-08, Vol.90B (2), p.510-520
Miro-Mur, Francesc
Hindié, Mathilde
Kandhaya-Pillai, Renuka
Tobajas, Vanessa
Schwartz Jr, Simo
Alijotas-Reig, Jaume
2009
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Miro-Mur, Francesc
Hindié, Mathilde
Kandhaya-Pillai, Renuka
Tobajas, Vanessa
Schwartz Jr, Simo
Alijotas-Reig, Jaume
Titel
Medical-grade silicone induces release of proinflammatory cytokines in peripheral blood mononuclear cells without activating T cells
Ist Teil von
Journal of biomedical materials research. Part B, Applied biomaterials, 2009-08, Vol.90B (2), p.510-520
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2009
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
For more than 40 years, silicone implants had been employed in aesthetic, cosmetic medicine, and plastic surgery. Although adverse reactions produced by these products are rare, cases of immuno‐mediated reactions have been reported. To evaluate the aspects of immuno‐reactivity to medical‐grade silicone dermal filler, peripheral blood mononuclear cells (PBMC) of 39 individuals were studied. PBMC used include individuals with silicone injection‐related delayed adverse reactions, with silicone injections, and healthy control. Silicone induced production of TNF‐α and IL‐6 in all three groups. Notably, elevated production of IL‐6 was observed in nonstimulated PBMC and also the percentage of CD4+CD69+ T cells was higher in PHA‐stimulated PBMC from individuals with silicone injection‐related adverse reactions when compared with other two groups. However, IFN‐γ was not released in silicone‐stimulated or silicone+LPS‐stimulated PBMC from any group and no production of IL‐2 was measured indicating no proliferative response of PBMC. Subsequently, no CD4+CD69+ T cells were observed in these conditions. Finally, the inflammatory response in silicone‐stimulated cultures of monocyte‐derived macrophages with autologous lymphocytes is lesser than that observed in PBMC. In conclusion, silicone induces a release of proinflammatory cytokines but does not act as a polyclonal activator of CD4+ T cells. Thus, silicone is mounting an immune response in individuals with silicone‐related adverse effects but is not silicone antigen‐dependent. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
Sprache
Englisch
Identifikatoren
ISSN: 1552-4973, 1552-4981
eISSN: 1552-4981
DOI: 10.1002/jbm.b.31312
Titel-ID: cdi_proquest_miscellaneous_883026899
Format
–
Schlagworte
Adult
,
Aged
,
Antigens, CD - biosynthesis
,
Antigens, Differentiation, T-Lymphocyte - biosynthesis
,
Biomedical materials
,
Blood
,
CD4-Positive T-Lymphocytes - cytology
,
CD4-Positive T-Lymphocytes - metabolism
,
Cosmetics
,
Culture
,
Cytokines
,
Cytokines - metabolism
,
Female
,
Humans
,
Inflammation
,
Interferon-gamma - metabolism
,
Interleukin-6 - metabolism
,
late adverse reactions
,
Lectins, C-Type
,
Leukocytes, Mononuclear - cytology
,
Lymphocytes
,
Male
,
Middle Aged
,
PBMC
,
silicone dermal filler
,
Silicones
,
Silicones - pharmacology
,
Surgical implants
,
Tumor Necrosis Factor-alpha - metabolism
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