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Cannabinoid receptor type 1 expression during postnatal development of the rat retina
Journal of comparative neurology (1911), 2011-05, Vol.519 (7), p.1258-1280
Zabouri, N.
Bouchard, J.-F.
Casanova, C.
2011
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Zabouri, N.
Bouchard, J.-F.
Casanova, C.
Titel
Cannabinoid receptor type 1 expression during postnatal development of the rat retina
Ist Teil von
Journal of comparative neurology (1911), 2011-05, Vol.519 (7), p.1258-1280
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2011
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Cannabinoid receptor type 1 (CB1R) participates in developmental processes in the central nervous system (CNS). The rodent retina represents an interesting and valuable model for studying CNS development, because it contains well‐identified cell types with clearly established and distinct developmental timelines. Very little is known about the distribution or function of CB1R in the developing retina. In this study, we investigated the expression pattern of CB1R in the rat retina during all stages of postnatal development. Western blots were performed on retinal tissue at different time points between P1 and adulthood. In order to identify the cells expressing the receptor and the age at which this expression started, immunohistochemical co‐staining was carried out for CB1R and markers of the different cell types comprising the retina. CB1R was already present at P1 in various cell types, i.e., ganglion, amacrine, horizontal, and mitotic cells. In the course of development, it appeared in cone photoreceptors and bipolar cells. For some cell types (bipolar, Müller, and some amacrine cells), CB1R was transiently expressed, suggesting a potential role of this receptor in developmental processes, such as migration, morphological changes, sub‐identity acquisition, and patterned retinal spontaneous activity. Our results also indicated that CB1R is largely expressed in the adult retina (cone photoreceptors and horizontal, most amacrine, and retinal ganglion cells), and may therefore contribute to retinal functions. Overall these results indicate that, as shown in other structures of the brain, CB1R could play an instrumental role in the development and function of the retina. J. Comp. Neurol. 519:1258–1280, 2011. © 2010 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0021-9967, 1096-9861
eISSN: 1096-9861
DOI: 10.1002/cne.22534
Titel-ID: cdi_proquest_miscellaneous_883026898
Format
–
Schlagworte
Animals
,
Biomarkers - metabolism
,
Cannabinoid Receptor Modulators - metabolism
,
CB1R
,
endocannabinoids
,
FAAH
,
immunohistochemistry
,
Mice
,
Mice, Inbred C57BL
,
Mice, Knockout
,
NAPE-PLD
,
Neurons - cytology
,
Neurons - metabolism
,
Rats
,
Rats, Long-Evans
,
Receptor, Cannabinoid, CB1 - genetics
,
Receptor, Cannabinoid, CB1 - metabolism
,
Retina - cytology
,
Retina - growth & development
,
Retina - metabolism
,
retinogenesis
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