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BibTeX
T2 measurement in articular cartilage: Impact of the fitting method on accuracy and precision at low SNR
Magnetic resonance in medicine, 2010-01, Vol.63 (1), p.181-193
Raya, José G.
Dietrich, Olaf
Horng, Annie
Weber, Jürgen
Reiser, Maximilian F.
Glaser, Christian
2010
Details
Autor(en) / Beteiligte
Raya, José G.
Dietrich, Olaf
Horng, Annie
Weber, Jürgen
Reiser, Maximilian F.
Glaser, Christian
Titel
T2 measurement in articular cartilage: Impact of the fitting method on accuracy and precision at low SNR
Ist Teil von
Magnetic resonance in medicine, 2010-01, Vol.63 (1), p.181-193
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
T2 relaxation time is a promising MRI parameter for the detection of cartilage degeneration in osteoarthritis. However, the accuracy and precision of the measured T2 may be substantially impaired by the low signal‐to‐noise ratio of images available from clinical examinations. The purpose of this work was to assess the accuracy and precision of the traditional fit methods (linear least‐squares regression and nonlinear fit to an exponential) and two new noise‐corrected fit methods: fit to a noise‐corrected exponential and fit of the noise‐corrected squared signal intensity to an exponential. Accuracy and precision have been analyzed in simulations, in phantom measurements, and in seven repetitive acquisitions of the patellar cartilage in six healthy volunteers. Traditional fit methods lead to a poor accuracy for low T2, with overestimations of the exact T2 up to 500%. The noise‐corrected fit methods demonstrate a very good accuracy for all T2 values and signal‐to‐noise ratio. Even more, the fit to a noise‐corrected exponential results in precisions comparable to the best achievable precisions (Cramér‐Rao lower bound). For in vivo images, the traditional fit methods considerably overestimate T2 near the bone‐cartilage interface. Therefore, using an adequate fit method may substantially improve the sensitivity of T2 to detect pathology in cartilage and change in T2 follow‐up examinations. Magn Reson Med, 2010. © 2009 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0740-3194, 1522-2594
eISSN: 1522-2594
DOI: 10.1002/mrm.22178
Titel-ID: cdi_proquest_miscellaneous_883020327
Format
–
Schlagworte
accuracy
,
Algorithms
,
cartilage
,
Cartilage (articular)
,
Cartilage diseases
,
Cartilage, Articular - anatomy & histology
,
Degeneration
,
Humans
,
Image Enhancement - methods
,
Image Interpretation, Computer-Assisted - methods
,
Magnetic resonance imaging
,
Magnetic Resonance Imaging - methods
,
N.M.R
,
Osteoarthritis
,
precision
,
Reproducibility of Results
,
Sensitivity and Specificity
,
SNR
,
T2 fitting
,
T2 relaxation time
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