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Human peripheral nerve-derived scaffold for tissue-engineered nerve grafts: Histology and biocompatibility analysis
Journal of biomedical materials research. Part B, Applied biomaterials, 2011-01, Vol.96B (1), p.25-33
Yang, Li-Min
Liu, Xiao-Lin
Zhu, Qing-Tang
Zhang, Yang
Xi, Ting-Fei
Hu, Jun
He, Cai-Feng
Jiang, Li
2011
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Yang, Li-Min
Liu, Xiao-Lin
Zhu, Qing-Tang
Zhang, Yang
Xi, Ting-Fei
Hu, Jun
He, Cai-Feng
Jiang, Li
Titel
Human peripheral nerve-derived scaffold for tissue-engineered nerve grafts: Histology and biocompatibility analysis
Ist Teil von
Journal of biomedical materials research. Part B, Applied biomaterials, 2011-01, Vol.96B (1), p.25-33
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2011
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Human acellular nerve grafts (ANGs) have been rarely used to construct tissue‐engineered nerves compared to the animal‐derived ANGs, and their potential clinical applications were relatively unknown. In this study, it was aimed to investigate the structure and components of a scaffold derived from human peripheral nerve and evaluate its biocompatibility. The human peripheral nerves were processed to prepare the scaffolds by chemical extraction. Light and electron microscopy were carried out to analyze scaffold structure and components. The analysis of cytotoxicity, hemolysis, and skin sensitization were performed to evaluate their biocompatibility. It was shown that Schwann cells and axons, identified by S‐100 and neurofilament (NF) expression, were absent, and the scaffolds were cell‐free and rich in collagen‐I and laminin whose microarchitecture was similar to the fibrous framework of human peripheral nerves. It was revealed from biocompatibility tests that the scaffolds had very mild cytotoxicity and hemolysis, whereas skin sensitization was not observed. The constructed human peripheral nerve‐derived scaffolds with well biocompatibility for clinical practice, which were cell‐free and possess the microstructure and extracellular matrix (ECM) of a human nerve, might be an optimal scaffold for tissue‐engineered nerve grafts in human. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.
Sprache
Englisch
Identifikatoren
ISSN: 1552-4973, 1552-4981
eISSN: 1552-4981
DOI: 10.1002/jbm.b.31719
Titel-ID: cdi_proquest_miscellaneous_883016333
Format
–
Schlagworte
Animals
,
Antigens, Differentiation - biosynthesis
,
Axons - metabolism
,
Biocompatibility
,
Biological and medical sciences
,
Biomedical materials
,
Biotechnology
,
Cell Line
,
Fundamental and applied biological sciences. Psychology
,
Gene Expression Regulation
,
Grafts
,
Guinea Pigs
,
Health. Pharmaceutical industry
,
histology
,
Human
,
human acellular nerve graft
,
Humans
,
Industrial applications and implications. Economical aspects
,
Materials Testing - methods
,
Medical sciences
,
Mice
,
Miscellaneous
,
Nerves
,
peripheral nerve
,
Peripheral Nerves
,
S100 Proteins - biosynthesis
,
Scaffolds
,
Schwann Cells - cytology
,
Schwann Cells - metabolism
,
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
,
Surgical implants
,
Technology. Biomaterials. Equipments
,
tissue engineering
,
Tissue Engineering - methods
,
Tissue Scaffolds
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