UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 7 von 40
Datensatz exportieren als...
BibTeX
The inhibitory neurotransmitter glycine modulates macrophage activity by activation of neutral amino acid transporters
Journal of neuroscience research, 2010-08, Vol.88 (11), p.2420-2430
Carmans, Sofie
Hendriks, Jerome J.A.
Thewissen, Kristof
Van den Eynden, Jimmy
Stinissen, Piet
Rigo, Jean-Michel
Hellings, Niels
2010
Details
Autor(en) / Beteiligte
Carmans, Sofie
Hendriks, Jerome J.A.
Thewissen, Kristof
Van den Eynden, Jimmy
Stinissen, Piet
Rigo, Jean-Michel
Hellings, Niels
Titel
The inhibitory neurotransmitter glycine modulates macrophage activity by activation of neutral amino acid transporters
Ist Teil von
Journal of neuroscience research, 2010-08, Vol.88 (11), p.2420-2430
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Link zum Volltext
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
Glycine, an important inhibitory neurotransmitter in the mammalian central nervous system (CNS), has been shown to modulate peripheral immune cell responses. In that respect, glycine levels are increased in several neuroinflammatory disorders, such as amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). In this study, we show that glycine modulates macrophage effector functions implicated in CNS inflammation and in other, related inflammatory conditions. We demonstrate that glycine does not affect the production of reactive oxygen species but stimulates myelin phagocytosis and the production of the proinflammatory mediators nitric oxide (NO) and tumor necrosis factor (TNF)‐α by rat macrophages. These effects of glycine are not mediated by the glycine receptor (GlyR) or by glycine transporters (GlyTs), as neither the GlyR antagonist strychnine nor the antagonist of GlyT1 (ALX5407) reverses the observed effects. In contrast, 2‐aminoisobutyric acid, a substrate of neutral amino acid transporters (NAATs), inhibits the glycine‐mediated enhancement of myelin phagocytosis as well as of NO and TNF‐α production. In conclusion, our findings demonstrate that glycine modulates macrophage function through activation of NAATs. Glycine may thereby influence immunological processes in inflammatory diseases involving macrophage activation and demyelination, including MS and related conditions associated with altered glycine levels. © 2010 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0360-4012, 1097-4547
eISSN: 1097-4547
DOI: 10.1002/jnr.22395
Titel-ID: cdi_proquest_miscellaneous_883015285
Format
–
Schlagworte
Amino Acid Transport Systems, Neutral - metabolism
,
Animals
,
Biotransformation - drug effects
,
Cell Proliferation - drug effects
,
Cell Survival
,
Dose-Response Relationship, Drug
,
Fluorescent Antibody Technique
,
glycine
,
Glycine - pharmacology
,
Glycine Agents - pharmacology
,
Inflammation - pathology
,
macrophage
,
Macrophages, Peritoneal - drug effects
,
Male
,
multiple sclerosis
,
Multiple Sclerosis - metabolism
,
Myelin Sheath - physiology
,
neuroinflammation
,
Neurotransmitter Agents - pharmacology
,
neutral amino acid transporter
,
Nitric Oxide - biosynthesis
,
Phagocytosis - drug effects
,
Rats
,
Rats, Wistar
,
Reactive Oxygen Species - metabolism
,
Receptors, Glycine - biosynthesis
,
Receptors, Glycine - genetics
,
Reverse Transcriptase Polymerase Chain Reaction
,
Strychnine - pharmacology
,
Tumor Necrosis Factor-alpha - biosynthesis
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX