Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (2), p.664-669
2011
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (2), p.664-669
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We herein report the discovery of four series of fused 5,6-bicyclic heterocycles as γ-secretase modulators. Synthesis and SAR of these series are discussed. These compounds represent a new class of γ-secretase modulators that demonstrate moderate to good in vitro potency in inhibiting Aβ 42 production.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2010.12.012Titel-ID: cdi_proquest_miscellaneous_883012978
- Format
- –
- Schlagworte
- Alzheimer Disease - drug therapy, Alzheimer’s disease, amyloid, Amyloid beta-Peptides - antagonists & inhibitors, Amyloid beta-Peptides - metabolism, Amyloid Precursor Protein Secretases - metabolism, Amyloid-β peptide, Animals, Biological and medical sciences, Bridged Bicyclo Compounds, Heterocyclic - chemistry, Bridged Bicyclo Compounds, Heterocyclic - pharmacokinetics, Bridged Bicyclo Compounds, Heterocyclic - pharmacology, heterocyclic compounds, Humans, Medical sciences, Neuropharmacology, Notch receptor, Pharmacology. Drug treatments, proteinase inhibitors, proteinases, Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer, Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease), Psychology. Psychoanalysis. Psychiatry, Psychopharmacology, Rats, Structure-Activity Relationship, structure-activity relationships, γ-Secretase modulator