Lancet neurology, 2008-12, Vol.7 (12), p.1127-1138
2008
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Details
- Autor(en) / Beteiligte
- Titel
- Hereditary spastic paraplegia: clinical features and pathogenetic mechanisms
- Ist Teil von
- Lancet neurology, 2008-12, Vol.7 (12), p.1127-1138
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Summary Hereditary spastic paraplegia (HSP) describes a heterogeneous group of genetic neurodegenerative disorders in which the most severely affected neurons are those of the spinal cord. These disorders are characterised clinically by progressive spasticity and weakness of the lower limbs, and pathologically by retrograde axonal degeneration of the corticospinal tracts and posterior columns. In recent years, genetic studies have identified key cellular functions that are vital for the maintenance of axonal homoeostasis in HSP. Here, we describe the clinical and diagnostic features of the various forms of HSP. We also discuss the genes that have been identified and the emerging pathogenic mechanisms.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1474-4422eISSN: 1474-4465DOI: 10.1016/S1474-4422(08)70258-8Titel-ID: cdi_proquest_miscellaneous_879482569
- Format
- –
- Schlagworte
- Age, Ataxia, Axons - metabolism, Axons - pathology, Central Nervous System - pathology, Central Nervous System - physiopathology, Family medical history, Genetic Predisposition to Disease - genetics, Heat shock proteins, Hereditary spastic parplegia, Humans, Inheritance Patterns - genetics, Limbs, Mutation, Mutation - genetics, Nerve Degeneration - genetics, Nerve Degeneration - pathology, Nerve Degeneration - physiopathology, Nerve Tissue Proteins - genetics, Neural Pathways - pathology, Neural Pathways - physiopathology, Neurodegeneration, Neurodegenerative diseases, Neurology, Neurons, Paralysis, Pyramidal tracts, Spastic Paraplegia, Hereditary - genetics, Spastic Paraplegia, Hereditary - pathology, Spastic Paraplegia, Hereditary - physiopathology, Spasticity, Spinal cord