Details

Autor(en) / Beteiligte

• Liang, Shu-xuan
• Gao, Hong-xia
• Zhao, Yan-yan
• Ma, Xiao-mei
• Sun, Han-wen

Titel

Effects of repeated exposure to decabrominated diphenyl ether (BDE-209) on mice nervous system and its self repair

Ist Teil von

• Environmental toxicology and pharmacology, 2010-05, Vol.29 (3), p.297-301

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2010

Quelle

ScienceDirect

Beschreibungen/Notizen

• Abstract Decabrominated diphenyl ether (BDE-209) is widely used as brominated flame retardants (BFRs). In order to investigate its direct neurotoxic effects on mice and its self repair, mice were repeatedly exposured to BDE-209. Different concentrations of BDE-209 (0, 0.1, 40, 80 and 160 mg/kg bw/d) were administered daily to CD-1 Swiss mice by gavage for 15, 30 and 60 days. Body and brain weights were recorded after the exposure. And the self repair was studied. Levels of acetylcholinesterase (TchE), superoxide dismutase (SOD) and malonic dialdehyde (MDA) in brain were analyzed. Experimental results suggested that the nervous system was permanently damaged by BDE-209 through the cholinergic system enzyme.