Nature neuroscience, 2008-12, Vol.11 (12), p.1381-1382
2008
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- Autor(en) / Beteiligte
- Titel
- Dopamine in amygdala gates limbic processing of aversive stimuli in humans
- Ist Teil von
- Nature neuroscience, 2008-12, Vol.11 (12), p.1381-1382
- Ort / Verlag
- New York: Nature Publishing Group US
- Erscheinungsjahr
- 2008
- Quelle
- EBSCOhost Psychology and Behavioral Sciences Collection
- Beschreibungen/Notizen
- Dopamine is released under stress and modulates processing of aversive stimuli. We found that dopamine storage capacity in human amygdala, measured with 6-[18F]fluoro-L-DOPA positron emission tomography, was positively correlated with functional magnetic resonance imaging blood oxygen level-dependent signal changes in amygdala and dorsal anterior cingulate cortex that were evoked by aversive stimuli. Furthermore, functional connectivity between these two regions was inversely related to trait anxiety. Our results suggest that individual dopamine storage capacity in amygdala subserves modulation of emotional processing in amygdala and dorsal cingulate, thereby contributing to individual differences in anxious temperament.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1097-6256eISSN: 1546-1726DOI: 10.1038/nn.2222Titel-ID: cdi_proquest_miscellaneous_877602357
- Format
- –
- Schlagworte
- Adult, Affect, Amygdala (Brain), Amygdala - blood supply, Amygdala - diagnostic imaging, Amygdala - metabolism, Animal Genetics and Genomics, Anxiety, Behavioral Sciences, Biological Techniques, Biomedical and Life Sciences, Biomedicine, Brain Mapping, brief-communication, Dihydroxyphenylalanine - analogs & derivatives, Dihydroxyphenylalanine - pharmacokinetics, Dopamine, Dopamine - metabolism, Fluorine Radioisotopes - pharmacokinetics, Gyrus Cinguli - blood supply, Gyrus Cinguli - diagnostic imaging, Humans, Image Processing, Computer-Assisted, Limbic System - diagnostic imaging, Limbic System - metabolism, Magnetic resonance imaging, Magnetic Resonance Imaging - methods, Male, Measurement, Medical imaging, Mental disorders, Middle Aged, Neurobiology, Neuroimaging, Neurosciences, Nuclear medicine, Oxygen - blood, Physiological aspects, Positron-Emission Tomography - methods, Psychiatry, Psychophysics, Psychotherapy, Tomography