Details

Autor(en) / Beteiligte

• Guey, Lin T., PhD
• Pullinger, Clive R., PhD
• Ishida, Brian Y., PhD
• O'Connor, Patricia M., MD
• Zellner, Christian, MD
• Francone, Omar L., PhD
• Laramie, Jason M., PhD
• Naya-Vigne, Josefina M., MD
• Siradze, Ketevan A., MD
• Deedwania, Prakash, MD
• Redberg, Rita F., MD
• Frost, Philip H., MD
• Seymour, Albert B., PhD
• Kane, John P., MD, PhD
• Malloy, Mary J., MD

Titel

Relation of Increased Prebeta-1 High-Density Lipoprotein Levels to Risk of Coronary Heart Disease

Ist Teil von

• The American journal of cardiology, 2011-08, Vol.108 (3), p.360-366

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2011

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Preβ-1 high-density lipoprotein (HDL) plays a key role in reverse cholesterol transport by promoting cholesterol efflux. Our aims were (1) to test previous associations between preβ-1 HDL and coronary heart disease (CHD) and (2) to investigate whether preβ-1 HDL levels also are associated with risk of myocardial infarction (MI). Plasma preβ-1 HDL was measured by an ultrafiltration–isotope dilution technique in 1,255 subjects recruited from the University of California–San Francisco Lipid and Cardiovascular Clinics and collaborating cardiologists. Preβ-1 HDL was significantly and positively associated with CHD and MI even after adjustment for established risk factors. Inclusion of preβ-1 HDL in a multivariable model for CHD led to a modest improvement in reclassification of subjects (net reclassification index 0.15, p = 0.01; integrated discrimination improvement 0.003, p = 0.2). In contrast, incorporation of preβ-1 HDL into a risk model of MI alone significantly improved reclassification of subjects (net reclassification index 0.21, p = 0.008; integrated discrimination improvement 0.01, p = 0.02), suggesting that preβ-1 HDL has more discriminatory power for MI than for CHD in our study population. In conclusion, these results confirm previous associations between preβ-1 HDL and CHD in a large well-characterized clinical cohort. Also, this is the first study in which preβ-1 HDL was identified as a novel and independent predictor of MI above and beyond traditional CHD risk factors.