Details

Autor(en) / Beteiligte

• Guan, Bing, MD, PhD
• Wang, Hai, MD
• Cao, Shougen, MD, PhD
• Rao, Qiu, MD, PhD
• Wang, Yan, MD, PhD
• Zhu, Yun, PhD
• Shi, Qunli, MD
• Yin, Honglin, MD
• Wang, Xuan, BD
• Zhou, Xiaojun, MD, PhD

Titel

Lipid-rich carcinoma of the breast clinicopathologic analysis of 17 cases

Ist Teil von

• Annals of diagnostic pathology, 2011-08, Vol.15 (4), p.225-232

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Lipid-rich carcinoma of the breast is a rare variant of breast cancer, accounted for <1% of all breast malignant tumors. We retrospectively analyzed the clinicopathologic characteristics of lipid-rich carcinomas of the breast. A panel of estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2 (HER-2), cytokeratin (CK) 5/6, CK14, and P63 was prepared for detection of lipid-rich carcinoma. Fluorescence in situ hybridization and electron microscope assays were performed for detecting HER-2 gene amplification and ultrastructure. Survival analysis were carried out using Kaplan-Meier and Cox regression methods. Receiver operating characteristic test was also performed. Estrogen receptor, CK5/6, CK14, and P63 were negative. Progesterone receptor (1/17) and HER-2 (17/17) were positive. HER-2 gene amplification was detected in all included cases (ratio values >2.2). Ultrastructure showed fat droplet and electron-dense material in the cytoplasm. Statistical differences were detected among survival and age ( P = .033), histologic grade ( P = .004), lymph node involvement ( P = .001), and HER-2 expression ( P = .002), respectively, using Kaplan-Meier methods. Statistical differences were also detected ( P = .017) using Cox regression methods. Receiver operating characteristic test displayed significant statistical differences; the prognosis had a correlation between HER-2 expression “+” and HER-2 expression “++” ( P = .004). Lipid-rich carcinoma of the breast was an HER-2 overexpressing subtype of the breast carcinoma. Survival of lipid-rich carcinoma might be associated with age, histologic grade, lymph node involvement, and HER-2. The HER-2 expression, however, might play an important role in predicting the prognosis of lipid-rich carcinoma of the breast.