Details

Autor(en) / Beteiligte

• Baldomero, H
• Gratwohl, M
• Gratwohl, A
• Tichelli, A
• Niederwieser, D
• Madrigal, A
• Frauendorfer, K

Titel

The EBMT activity survey 2009: trends over the past 5 years

Ist Teil von

• Bone marrow transplantation (Basingstoke), 2011-04, Vol.46 (4), p.485-501

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• Six hundred and twenty-four centers from 43 countries reported a total of 31 322 hematopoietic SCT (HSCT) to this 2009 European Group for Blood and Marrow Transplantation (EBMT) survey with 28 033 first transplants (41% allogeneic, 59% autologous). The main indications were leukemias (31%; 92% allogeneic), lymphomas (58%; 12% allogeneic), solid tumors (5%; 6% allogeneic) and non-malignant disorders (6%; 88% allogeneic). There were more unrelated than HLA-identical sibling donors (51 vs 43%) for allogeneic HSCT; the proportion of peripheral blood as stem cell source was 99% for autologous and 71% for allogeneic HSCT. Allogeneic and autologous HSCT continued to increase by about 1000 HSCT per year since 2004. Patterns of increase were distinct and different. In a trend analysis, allogeneic HSCT increased in all World Bank Categories ( P =0.01, two sided; all categories), autologous HSCT increased in middle- ( P =0.01, two sided) and low-income ( P =0.01, two sided) countries. EBMT practice guidelines appeared to have an impact on trend, with a clear increase in absolute numbers within the categories ‘standard’ and ‘clinical option’ for both allogeneic and autologous HSCT ( P =0.01, two sided; for both allogeneic and autologous HSCT) and a clear decrease in autologous HSCT for the ‘developmental’ and ‘generally not recommended’ indications ( P =0.01, two sided). These data illustrate the status and trends of HST in Europe.