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Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy
Pediatric blood & cancer, 2011-09, Vol.57 (3), p.415-422
Hegyi, Marta
Semsei, Agnes F.
Jakab, Zsuzsanna
Antal, Imre
Kiss, Janos
Szendroi, Miklos
Csoka, Monika
Kovacs, Gabor
2011
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Hegyi, Marta
Semsei, Agnes F.
Jakab, Zsuzsanna
Antal, Imre
Kiss, Janos
Szendroi, Miklos
Csoka, Monika
Kovacs, Gabor
Titel
Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy
Ist Teil von
Pediatric blood & cancer, 2011-09, Vol.57 (3), p.415-422
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2011
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Background The objective of this report was to estimate long‐term outcome and prognostic factors in children and adolescents with osteosarcoma. A large group of osteosarcoma patients were analyzed at our national oncology center. Procedure To evaluate the efficacy of surgery and multiagent chemotherapy for treating osteosarcoma, we reviewed 122 cases (65 male, 57 female, mean age 13.8 ± 3.6 years) treated at the Second Department of Pediatrics in Budapest between 1988 and 2006. Demographic parameters, tumor‐related and treatment‐related variables, response, overall survival (OS) and event‐free survival (EFS) were analyzed. Results The 5‐year OS was 68% and 5‐year EFS was 62%. OS of patients without metastasis was 79%, while OS with early metastasis was 17%. Survival of patients with amputation (n = 30) was not significantly different from patients with limb‐salvage surgery (n = 82), but all patients without radical surgery died. Gender and histological classification had no prognostic significance. Patients with localized tumors in extremities had increased survival compared to patients with axial skeleton tumors (P = 0.013). Poor histological response to neoadjuvant chemotherapy (rate of survivor tumor cells >10%) was associated with decreased survival (P = 0.018). Patients under 14 years had better EFS than patients over 14 years (P = 0.008). Conclusions Our results demonstrate that younger patients with localized osteosarcoma of the extremities who receive limb‐salvage surgery and chemotherapy have an excellent survival. Pediatr Blood Cancer 2011; 57: 415–422. © 2011 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1545-5009
eISSN: 1545-5017
DOI: 10.1002/pbc.23172
Titel-ID: cdi_proquest_miscellaneous_876191854
Format
–
Schlagworte
Adolescent
,
Age Factors
,
Amputation - mortality
,
Antineoplastic Agents - therapeutic use
,
chemotherapy
,
Child
,
Female
,
Humans
,
Limb Salvage - mortality
,
Male
,
Neoplasm Metastasis
,
osteosarcoma
,
Osteosarcoma - mortality
,
Osteosarcoma - therapy
,
outcome research
,
pediatric oncology
,
Prognosis
,
Retrospective Studies
,
Risk Factors
,
Survival Analysis
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