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We carried out an extensive simulative analysis to investigate in depth the potential of electronic dispersion compensation (EDC) in amplified multispan 111-Gb/s wavelength- division-multiplexed systems based on polarization-multiplexed quadrature phase-shift keying modulation with coherent detection, also in the presence of substantial fiber nonlinearity. For typical single-mode and nonzero dispersion-shifted fibers, our results show that the use of inline optical dispersion management is always suboptimal versus using EDC at the receiver.