The New England journal of medicine, 2011-06, Vol.364 (26), p.2483-2495
2011
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Details
- Autor(en) / Beteiligte
- Titel
- Mortality after Fluid Bolus in African Children with Severe Infection
- Ist Teil von
- The New England journal of medicine, 2011-06, Vol.364 (26), p.2483-2495
- Ort / Verlag
- Waltham, MA: Massachusetts Medical Society
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- In this study from sub-Saharan Africa, children with severe febrile illness and impaired perfusion were randomly assigned to fluid-bolus therapy or no bolus. Albumin or saline boluses significantly increased 48-hour mortality in critically ill children with impaired perfusion. Rapid, early fluid resuscitation in patients with shock, a therapy that is aimed at the correction of hemodynamic abnormalities, is one component of goal-driven emergency care guidelines. This approach is widely endorsed by pediatric life-support training programs, which recommend the administration of up to 60 ml of isotonic fluid per kilogram of body weight within 15 minutes after the diagnosis of shock. 1 Children who do not have an adequate response to fluid resuscitation require intensive care for inotropic and ventilatory support. 1 Substantial improvements in the outcomes of pediatric septic shock have been attributed to this approach. 2 , 3 Nevertheless, evidence regarding . . .
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-4793eISSN: 1533-4406DOI: 10.1056/NEJMoa1101549Titel-ID: cdi_proquest_miscellaneous_874483355
- Format
- –
- Schlagworte
- Acidosis, Africa, Eastern, Age, Albumin, Albumins - administration & dosage, Biological and medical sciences, Body weight, Child, Child mortality, Child, Preschool, Children, Clinical trials, Coma, Committees, Councils, Critical Illness - mortality, Critical Illness - therapy, Edema, Emergency medical care, Epidemiology, Female, Fever, Fluid Therapy - methods, Fluid Therapy - mortality, Fluids, Gastroenteritis, General aspects, Humans, Hypotension, Hypotension - therapy, Infant, Infections - mortality, Infections - therapy, Intensive care, Intention to Treat Analysis, Intravenous administration, Malaria, Male, Malnutrition, Medical research, Medical sciences, Mortality, Neurological complications, Pediatrics, Perfusion, Pressure, Public health. Hygiene, Public health. Hygiene-occupational medicine, Resuscitation - methods, Risk, Sepsis, Shock - mortality, Shock - therapy, Sodium Chloride - administration & dosage, Young, Natalie