Details

Autor(en) / Beteiligte

• ALLAN, Amanda C
• BILLINTON, Andy
• NAYLOR, Alan
• RAWLINGS, D. Anthony
• SIME, Mairi
• SCOCCITTI, Tiziana
• THEOBALD, Pamela J
• BROWN, Susan H
• CHOWDHURY, Anita
• EATHERTON, Andrew J
• FIELDHOUSE, Charlotte
• GIBLIN, Gerard M. P
• GOLDSMITH, Paul
• HALL, Adrian
• HURST, David N

Titel

Discovery of a novel series of nonacidic benzofuran EP1 receptor antagonists

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2011-07, Vol.21 (14), p.4343-4348

Ort / Verlag

Amsterdam: Elsevier

Erscheinungsjahr

2011

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• We describe the discovery and optimization of a novel series of benzofuran EP(1) antagonists, leading to the identification of 26d, a novel nonacidic EP(1) antagonist which demonstrated efficacy in preclinical models of chronic inflammatory pain.