Details

Autor(en) / Beteiligte

• TSAI, Miao-Chih
• SPITALE, Robert C
• CHANG, Howard Y

Titel

Long Intergenic Noncoding RNAs: New Links in Cancer Progression

Ist Teil von

• Cancer research (Chicago, Ill.), 2011, Vol.71 (1), p.3-7

Ort / Verlag

Philadelphia, PA: American Association for Cancer Research

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• The process of cancer metastasis involves a series of sequential and complex steps. Here we give a perspective on recent results regarding noncoding transcription in cancer progression, focusing on the emerging role of long intergenic noncoding RNAs (lincRNAs). LincRNAs target chromatin modification complexes or RNA-binding proteins to alter gene expression programs. Similarly to miRNAs, lincRNAs exhibit distinct gene expression patterns in primary tumors and metastases. We discuss how lincRNAs can be used for cancer diagnosis and prognosis and serve as potential therapeutic targets.