Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.3029-3033
2011
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Novel N-chloroheterocyclic antimicrobials
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.3029-3033
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A novel series of N-chloroheterocycles has been prepared and the biological properties are reported. Antimicrobial compounds with broad-spectrum activity and minimal potential for antibiotic resistance are urgently needed. Toward this end, we prepared and investigated a novel series of N-chloroheterocycles. Of the compounds examined, the N-chloroamine series were found superior over N-chloroamide series in regards to exhibiting high antimicrobial activity, low cytotoxicity, and long-term aqueous stability.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2011.03.035Titel-ID: cdi_proquest_miscellaneous_874190070
- Format
- –
- Schlagworte
- anti-infective agents, Anti-Infective Agents - chemical synthesis, Anti-Infective Agents - chemistry, Anti-Infective Agents - pharmacology, anti-infective properties, Antibacterial agents, antibiotic resistance, Antibiotics. Antiinfectious agents. Antiparasitic agents, Antifungal agents, Antimicrobials, Bacteria - drug effects, Biological and medical sciences, Broad-spectrum, chemistry, Chlorine - chemistry, cytotoxicity, Fungi - drug effects, General aspects, Heterocyclic Compounds - chemical synthesis, Heterocyclic Compounds - chemistry, Heterocyclic Compounds - pharmacology, Medical sciences, Microbial Sensitivity Tests, Molecular Structure, N-Chloroheterocyclic, Pharmacology. Drug treatments