Journal of dairy science, 2011-07, Vol.94 (7), p.3484-3494
2011
Details
- Autor(en) / Beteiligte
- Titel
- Endocrine changes and liver mRNA abundance of somatotropic axis and insulin system constituents during negative energy balance at different stages of lactation in dairy cows
- Ist Teil von
- Journal of dairy science, 2011-07, Vol.94 (7), p.3484-3494
- Ort / Verlag
- New York, NY: Elsevier Inc
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The liver has an important role in metabolic regulation and control of the somatotropic axis to adapt successfully to physiological and environmental changes in dairy cows. The aim of this study was to investigate the adaptation to negative energy balance (NEB) at parturition and to a deliberately induced NEB by feed restriction at 100 days in milk. The hepatic gene expression and the endocrine system of the somatotropic axis and related parameters were compared between the early and late NEB period. Fifty multiparous cows were subjected to 3 periods (1=early lactation up to 12 wk postpartum, 2=feed restriction for 3 wk beginning at around 100 days in milk with a feed-restricted and a control group, and 3=subsequent realimentation period for the feed-restricted group for 8 wk). In period 1, plasma growth hormone reached a maximum in early lactation, whereas insulin-like growth factor-I (IGF-I), leptin, the thyroid hormones, insulin, and the revised quantitative insulin sensitivity check index increased gradually after a nadir in early lactation. Three days after parturition, hepatic mRNA abundance of growth hormone receptor 1A, IGF-I, IGF-I receptor and IGF-binding protein-3 (IGFBP-3) were decreased, whereas mRNA of IGFBP-1 and -2 and insulin receptor were upregulated as compared with wk 3 antepartum. During period 2, feed-restricted cows showed decreased plasma concentrations of IGF-I and leptin compared with those of control cows. The revised quantitative insulin sensitivity check index was lower for feed-restricted cows (period 2) than for control cows. Compared with the NEB in period 1, the changes due to the deliberately induced NEB (period 2) in hormones were less pronounced. At the end of the 3-wk feed restriction, the mRNA abundance of IGF-I, IGFBP-1, -2, -3, and insulin receptor was increased as compared with the control group. The different effects of energy deficiency at the 2 stages in lactation show that the endocrine regulation changes qualitatively and quantitatively during the course of lactation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-0302eISSN: 1525-3198DOI: 10.3168/jds.2011-4251Titel-ID: cdi_proquest_miscellaneous_873706643
- Format
- –
- Schlagworte
- Animal productions, Animals, Biological and medical sciences, Cattle - blood, Cattle - metabolism, Cattle - physiology, dairy cows, early lactation, endocrine system, Endocrine System - metabolism, energy balance, Energy Metabolism, Female, Food Deprivation, Food industries, Fundamental and applied biological sciences. Psychology, gene expression, gene expression regulation, Growth Hormone - blood, hormone, insulin, insulin receptors, insulin resistance, Insulin-Like Growth Factor Binding Protein 1 - blood, Insulin-Like Growth Factor Binding Protein 1 - genetics, Insulin-Like Growth Factor Binding Protein 2 - blood, Insulin-Like Growth Factor Binding Protein 2 - genetics, Insulin-Like Growth Factor Binding Protein 3 - blood, Insulin-Like Growth Factor Binding Protein 3 - genetics, insulin-like growth factor I, Insulin-Like Growth Factor I - analysis, Insulin-Like Growth Factor I - genetics, insulin-like growth factor I receptor, Lactation - physiology, leptin, liver, Liver - metabolism, messenger RNA, Milk and cheese industries. Ice creams, negative energy balance, parturition, Receptor, Insulin - blood, Receptor, Insulin - genetics, repletion, restricted feeding, RNA, Messenger - metabolism, Sequence Analysis, RNA, somatotropic axis, somatotropin, somatotropin receptors, Terrestrial animal productions, thyroid hormones, Vertebrates