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Implications of Obesity for Drug Therapy: Limitations and Challenges
Ist Teil von
Clinical pharmacology and therapeutics, 2011-07, Vol.90 (1), p.77-89
Ort / Verlag
Basingstoke: Nature Publishing Group
Erscheinungsjahr
2011
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Obesity has become a worldwide challenge with significant health and socioeconomic implications. One of the major implications is its impact on drug therapy. In order to gain a better understanding of this impact, we surveyed the regulatory guidances, the newly approved molecular entity drug products, and drug product labels in the Physician's Desk Reference. This review summarizes the findings of the survey along with the existing knowledge on pharmacokinetic and pharmacodynamic changes associated with obesity.
Clinical Pharmacology & Therapeutics (2011) 90 1, 77–89. doi:10.1038/clpt.2011.104