Details

Autor(en) / Beteiligte

• Kurumurthy, C.
• Sambasiva Rao, P.
• Veera swamy, B.
• Santhosh kumar, G.
• Shanthan Rao, P.
• Narsaiah, B.
• Velatooru, L.R.
• Pamanji, R.
• Venkateswara Rao, J.

Titel

Synthesis of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives and their anticancer activity

Ist Teil von

• European journal of medicinal chemistry, 2011-08, Vol.46 (8), p.3462-3468

Ort / Verlag

Kidlington: Elsevier Masson SAS

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• A series of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives 5 and 6 was prepared starting from 2,3-active functional pyridine 1 via cyclization, propargylation followed by reaction with alkyl or perfluoroalkyl azides under Sharpless conditions. All the compounds 5 and 6 were screened for anticancer activity against three cancer cell lines such as U 937, THP-1 and Colo205. The promising compounds 5b and 5e have been identified. A series of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives 5 and 6 was prepared, screened for anticancer activity against three cancer cell lines and identified promising compounds 5b and 5e. [Display omitted] ► Sulphuric acid catalysed synthesis of novel pyrido[2,3-d]pyrimidine-4(3H)ones. ► Propargylation to obtain O- and N-propargylated pyrido[2,3-d]pyrimidines. ► Each isomer was reacted with alkyl azide under Sharpless conditions. ► Exclusively 1,4-disubstituted triazole tagged pyrido[2,3-d]pyrimidines formed. ► Final products screened for anticancer activity against three cancer cell lines.