Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (8), p.2403-2405
2011
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Details
- Autor(en) / Beteiligte
- Titel
- Small-molecule probe using dual signals to monitor leucine aminopeptidase activity
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (8), p.2403-2405
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- In this paper, we report a small-molecule probe which exhibits colorimetric and fluorogenic changes according to LAP activity. Leucine aminopeptidases (LAPs) are widely distributed in organisms from bacteria to humans, and play crucial roles in cell maintenance and cell growth. Thus, assays for LAP are necessary for measuring its activity and inhibitor potency. In this Letter, we report a small-molecule probe which exhibits colorimetric and fluorogenic changes according to LAP activity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2011.02.068Titel-ID: cdi_proquest_miscellaneous_872142618
- Format
- –
- Schlagworte
- 2-Dicyanomethylene-3-cyano-2,5-dihydrofuran (DCDHF) unit, Analytical, structural and metabolic biochemistry, bacteria, Biological and medical sciences, Calorimetry - methods, cell growth, Cell Line, Tumor, colorimetry, Dual signals, Enzymes and enzyme inhibitors, Fluorescent Dyes - chemistry, Fluorescent Dyes - pharmacology, Fundamental and applied biological sciences. Psychology, Furans - chemistry, Furans - pharmacology, Humans, Hydrolases, Kinetics, Leucine aminopeptidases, leucyl aminopeptidase, Leucyl Aminopeptidase - antagonists & inhibitors, Leucyl Aminopeptidase - metabolism, Nitriles - chemistry, Nitriles - pharmacology, Probe, Protease Inhibitors - chemistry, Protease Inhibitors - pharmacology, Small Molecule Libraries - chemistry, Small Molecule Libraries - pharmacology