Details

Autor(en) / Beteiligte

• Smith, Craig R
• Leon, Martin B
• Mack, Michael J
• Miller, D. Craig
• Moses, Jeffrey W
• Svensson, Lars G
• Tuzcu, E. Murat
• Webb, John G
• Fontana, Gregory P
• Makkar, Raj R
• Williams, Mathew
• Dewey, Todd
• Kapadia, Samir
• Babaliaros, Vasilis
• Thourani, Vinod H
• Corso, Paul
• Pichard, Augusto D
• Bavaria, Joseph E
• Herrmann, Howard C
• Akin, Jodi J
• Anderson, William N
• Wang, Duolao
• Pocock, Stuart J

Titel

Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients

Ist Teil von

• The New England journal of medicine, 2011-06, Vol.364 (23), p.2187-2198

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• This study examines use of an expandable bovine pericardial prosthetic valve inserted with a catheter system for valvular aortic stenosis. Outcomes were noninferior to those of surgical aortic-valve replacement, but the risk of stroke, aortic regurgitation, and vascular complications was substantial. After the appearance of symptoms, aortic stenosis is associated with a high rate of death if left untreated. 1 – 10 Although surgical aortic-valve replacement improves symptoms and survival, 11 – 15 observational studies have identified various subgroups of patients (i.e., those with an advanced age and those with poor left ventricular function or other coexisting disorders) who are at increased risk for operative complications or death. 16 – 21 In such patients, a less invasive treatment may be a desirable alternative. Transcatheter aortic-valve replacement treats aortic stenosis by displacing and functionally replacing the native valve with a bioprosthetic valve delivered on a catheter through the . . .