Pancreas, 2011-05, Vol.40 (4), p.634-637
2011
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- Autor(en) / Beteiligte
- Titel
- Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with multiple endocrine neoplasia type 1
- Ist Teil von
- Pancreas, 2011-05, Vol.40 (4), p.634-637
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We report a patient with multiple endocrine neoplasia type 1 presenting with elevation of parathyroid hormone-related protein (PTHrP) from a metastatic pancreatic neuroendocrine tumor (PNET), and parathyroid hormone (PTH) from primary hyperparathyroidism, resulting in severe hypercalcemia. Parathyroid hormone-related protein production by the PNET was confirmed by immunohistochemical analysis. Hypercalcemia and elevated PTHrP improved markedly with hepatic artery chemoembolization of liver metastasis. Thus, in multiple endocrine neoplasia type 1, correct identification of the cause of hypercalcemia as PTHrP production from a PNET or PTH production from a parathyroid tumor has important therapeutic implications.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0885-3177eISSN: 1536-4828DOI: 10.1097/MPA.0b013e318214f65eTitel-ID: cdi_crossref_primary_10_1097_MPA_0b013e318214f65e
- Format
- –
- Schlagworte
- Diagnosis, Differential, Humans, Hypercalcemia - complications, Hypercalcemia - diagnosis, Hypercalcemia - metabolism, Hyperparathyroidism, Primary - complications, Hyperparathyroidism, Primary - diagnosis, Hyperparathyroidism, Primary - metabolism, Male, Middle Aged, Multiple Endocrine Neoplasia Type 1 - complications, Multiple Endocrine Neoplasia Type 1 - diagnosis, Multiple Endocrine Neoplasia Type 1 - metabolism, Neuroendocrine Tumors - metabolism, Pancreatic Neoplasms - metabolism, Parathyroid Hormone - metabolism, Parathyroid Hormone-Related Protein - metabolism, Parathyroid Neoplasms - metabolism