Details

Autor(en) / Beteiligte

• Randall, Adrian
• Guye, Patrick
• Gupta, Saurabh
• Duportet, Xavier
• Weiss, Ron

Titel

Design and Connection of Robust Genetic Circuits

Ist Teil von

• Methods in Enzymology, 2011, Vol.497, p.159-186

Ort / Verlag

United States: Elsevier Science & Technology

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• Phenotypic robustness is a highly sought after goal for synthetic biology. There are many well-studied examples of robust systems in biology, and for the advancement of synthetic biology, particularly in performance-critical applications, fundamental understanding of how robustness is both achieved and maintained is very important. A synthetic circuit may fail to behave as expected for a multitude of reasons, and since many of these failures are difficult to predict a priori, a better understanding of a circuit’s behavior as well as its possible failures are needed. In this chapter, we outline work that has been done in developing design principles for robust synthetic circuits, as well as sharing our experiences designing and constructing gene circuits.