Details

Autor(en) / Beteiligte

• Spellmann, Ilja
• Rujescu, Dan
• Musil, Richard
• Mayr, Andreas
• Giegling, Ina
• Genius, Just
• Zill, Peter
• Dehning, Sandra
• Opgen-Rhein, Markus
• Cerovecki, Anja
• Hartmann, Annette M
• Schäfer, Martin
• Bondy, Brigitta
• Müller, Norbert
• Möller, Hans-Jürgen
• Riedel, Michael

Titel

Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients

Ist Teil von

• Journal of psychiatric research, 2011-02, Vol.45 (2), p.234-241

Ort / Verlag

Kidlington: Elsevier Ltd

Erscheinungsjahr

2011

Quelle

Applied Social Sciences Index & Abstracts (ASSIA)

Beschreibungen/Notizen

• Abstract The HOMER 1 protein plays a crucial role in mediating glutamatergic neurotransmission. It has previously shown to be a candidate gene for etiology and pathophysiology of different psychiatric diseases such as schizophrenia. To identify genes involved in response to antipsychotics, subgroups of animals were treated with haloperidol (1 mg/kg, n  = 11) or saline ( n  = 12) for one week. By analyzing microarray data, we replicated the observed increase of Homer 1 gene expression. Furthermore, we genotyped 267 schizophrenic patients, who were treated monotherapeutically with different antipsychotics within randomized-controlled trials. Psychopathology was measured weekly using the PANSS for a minimum of four and a maximum of twelve weeks. Correlations between PANSS subscale scores at baseline and PANSS improvement scores after four weeks of treatment and genotypes were calculated by using a linear model for all investigated SNP’s. We found an association between two HOMER 1 polymorphisms (rs2290639 and rs4704560) and different PANSS subscales at baseline. Furthermore all seven investigated polymorphisms were found to be associated with therapy response in terms of a significant correlation with different PANSS improvement subscores after four weeks of antipsychotic treatment. Most significant associations have been shown between the rs2290639 HOMER 1 polymorphism and PANSS subscales both at baseline conditions and after four weeks of antipsychotic treatment. This is the first study which shows an association between HOMER 1 polymorphisms and psychopathology data at baseline and therapy response in a clinical sample of schizophrenic patients. Thus, these data might further help in detecting differential therapy response in individuals with schizophrenia.