Nature structural & molecular biology, 2007-11, Vol.14 (11), p.1041-1048
2007
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- Autor(en) / Beteiligte
- Titel
- Transcription and RNAi in heterochromatic gene silencing
- Ist Teil von
- Nature structural & molecular biology, 2007-11, Vol.14 (11), p.1041-1048
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Recent findings have challenged the longstanding belief that heterochromatin is an inert and transcriptionally inactive structure. Studies in organisms ranging from fission yeast to animals have found that noncoding RNAs transcribed from heterochromatic DNA repeats function in the assembly and function of heterochromatin. In this review, we discuss the roles of RNA and RNA turnover in mechanisms that mediate heterochromatin assembly and keep heterochromatic domains silent.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1545-9993eISSN: 1545-9985DOI: 10.1038/nsmb1315Titel-ID: cdi_proquest_miscellaneous_868025194
- Format
- –
- Schlagworte
- Chromatin, Deoxyribonucleic acid, DNA, Eukaryota - genetics, Gene silencing, Genetic transcription, Heterochromatin - chemistry, Heterochromatin - genetics, Heterochromatin - metabolism, Models, Genetic, Molecular biology, Molecular structure, Physiological aspects, Ribonucleic acid, RNA, RNA - metabolism, RNA - physiology, RNA Interference - physiology, RNA, Small Interfering - metabolism, RNA, Small Interfering - physiology, Schizosaccharomyces pombe, Transcription, Genetic - physiology, Yeasts