Journal of neurochemistry, 2011-04, Vol.117 (1), p.19-28
2011
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- Autor(en) / Beteiligte
- Titel
- Low-n oligomers as therapeutic targets of Alzheimer's disease
- Ist Teil von
- Journal of neurochemistry, 2011-04, Vol.117 (1), p.19-28
- Ort / Verlag
- Oxford, UK: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2011
- Quelle
- Wiley InterScience Journals
- Beschreibungen/Notizen
- J. Neurochem. (2011) 117, 19-28. ABSTRACT: The pathogenesis of Alzheimer's disease involves the progressive accumulation of amyloid β-protein (Aβ). Recent studies using synthetic Aβ peptides, a cell culture model, Aβ precursor protein transgenic mice models suggest that pre-fibrillar forms of Aβ are more deleterious than extracellular fibril forms. Recent findings obtained using synthetic Aβ peptides and human samples indicated that low-n oligomers (from dimers to octamers) may be proximate toxins for neuron and synapse. Here, we review the recent studies on the soluble oligomers, especially low-n oligomers in Alzheimer's disease.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-3042eISSN: 1471-4159DOI: 10.1111/j.1471-4159.2011.07187.xTitel-ID: cdi_proquest_miscellaneous_867739623
- Format
- –
- Schlagworte
- Adult and adolescent clinical studies, Alzheimer Disease - drug therapy, Alzheimer Disease - metabolism, Alzheimer Disease - pathology, Alzheimer's disease, Amyloid beta-Peptides - chemistry, Amyloid beta-Peptides - genetics, Amyloid beta-Peptides - metabolism, amyloid β‐protein, Animals, Biological and medical sciences, Brain, Cells, Cultured, Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases, Dimerization, Disease Models, Animal, Drug Delivery Systems - methods, Humans, Medical sciences, Mice, Mice, Transgenic, Neurochemistry, Neurology, Neurons, oligomers, Organic mental disorders. Neuropsychology, Pathogenesis, Peptide Fragments - chemistry, Peptide Fragments - genetics, Peptide Fragments - metabolism, Psychology. Psychoanalysis. Psychiatry, Psychopathology. Psychiatry