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Is the magnetization transfer ratio a marker for myelin in multiple sclerosis?
Journal of magnetic resonance imaging, 2011-03, Vol.33 (3), p.710-718
Vavasour, Irene M.
Laule, Cornelia
Li, David K.B.
Traboulsee, Anthony L.
MacKay, Alex L.
2011
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Vavasour, Irene M.
Laule, Cornelia
Li, David K.B.
Traboulsee, Anthony L.
MacKay, Alex L.
Titel
Is the magnetization transfer ratio a marker for myelin in multiple sclerosis?
Ist Teil von
Journal of magnetic resonance imaging, 2011-03, Vol.33 (3), p.710-718
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2011
Quelle
MEDLINE
Beschreibungen/Notizen
Purpose To investigate the correlation between water content (WC) and magnetization transfer ratio (MTR) in normal and multiple sclerosis (MS) brain. The MTR has been proposed as a marker for myelin in central nervous system tissue. However, changes in WC due to inflammation and edema may also affect the MTR. Materials and Methods Seven MS subjects with active disease and seven age‐ and gender‐matched controls were scanned using quantitative magnetic resonance techniques. WC, myelin water content, T1 relaxation time, and MTR were calculated from areas of lesion (divided into new lesions less than 2 months old, isointense T1 lesions, and hypointense T1 lesions), contralateral normal‐appearing white matter (NAWM), and location‐matched normal white matter (NWM) in controls. Linear regression was used to determine the correlation between WC and MTR. Results A significant correlation was found between WC and MTR across all tissue (R = −0.65, P < 0.0005). Conclusion MTR was correlated with WC in MS tissue, indicating that inflammation and edema influence MTR. Therefore, caution should be used when associating MTR exclusively with myelin content. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1053-1807
eISSN: 1522-2586
DOI: 10.1002/jmri.22441
Titel-ID: cdi_proquest_miscellaneous_866531413
Format
–
Schlagworte
Adult
,
Biomarkers - metabolism
,
Edema - pathology
,
Female
,
Humans
,
Image Processing, Computer-Assisted
,
Inflammation
,
magnetic resonance imaging
,
Magnetic Resonance Imaging - methods
,
Magnetics
,
magnetization transfer
,
Male
,
Middle Aged
,
multiple sclerosis
,
Multiple Sclerosis - diagnosis
,
Multiple Sclerosis - pathology
,
Myelin Sheath - metabolism
,
myelin water content
,
T1 relaxation
,
Time Factors
,
Water - chemistry
,
water content
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