Details

Autor(en) / Beteiligte

• Grgurevic, Lovorka
• Macek, Boris
• Mercep, Mladen
• Jelic, Mislav
• Smoljanovic, Tomislav
• Erjavec, Igor
• Dumic-Cule, Ivo
• Prgomet, Stefan
• Durdevic, Dragan
• Vnuk, Drazen
• Lipar, Marija
• Stejskal, Marko
• Kufner, Vera
• Brkljacic, Jelena
• Maticic, Drazen
• Vukicevic, Slobodan

Titel

Bone morphogenetic protein (BMP)1-3 enhances bone repair

Ist Teil von

• Biochemical and biophysical research communications, 2011-04, Vol.408 (1), p.25-31

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2011

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• ►BMP1-3 isoform circulates in the human plasma. ► BMP1-3 has an important role in bone repair. ► BMP1-3 as a novel biomarker of bone regeneration. ► BMP1-3 enhances formation of mineralized bone matrix. ► BMP1-3 synergizes with BMP7 in bone defect repair. Members of the astacin family of metalloproteinases such as human bone morphogenetic protein 1 (BMP-1) regulate morphogenesis by processing precursors to mature functional extracellular matrix (ECM) proteins and several growth factors including TGFβ, BMP2, BMP4 and GFD8. We have recently discovered that BMP1-3 isoform of the Bmp-1 gene circulates in the human plasma and is significantly increased in patients with acute bone fracture. We hypothesized that circulating BMP1-3 might have an important role in bone repair and serve as a novel bone biomarker. When administered systemically to rats with a long bone fracture and locally to rabbits with a critical size defect of the ulna, recombinant human BMP1-3 enhanced bone healing. In contrast, neutralization of the endogenous BMP1-3 by a specific polyclonal antibody delayed the bone union. Invitro BMP1-3 increased the expression of collagen type I and osteocalcin in MC3T3-E1 osteoblast like cells, and enhanced the formation of mineralized bone nodules from bone marrow mesenchymal stem cells. We suggest that BMP1-3 is a novel systemic regulator of bone repair.