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Clinicopathologic factors of the recurrent tumor predict outcome in patients with ipsilateral breast tumor recurrence
Cancer, 2011-05, Vol.117 (10), p.2035-2043
Panet‐Raymond, Valerie
Truong, Pauline T.
Alexander, Cheryl
Lesperance, Mary
McDonald, Rachel E.
Watson, Peter H.
2011
Details
Autor(en) / Beteiligte
Panet‐Raymond, Valerie
Truong, Pauline T.
Alexander, Cheryl
Lesperance, Mary
McDonald, Rachel E.
Watson, Peter H.
Titel
Clinicopathologic factors of the recurrent tumor predict outcome in patients with ipsilateral breast tumor recurrence
Ist Teil von
Cancer, 2011-05, Vol.117 (10), p.2035-2043
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2011
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
BACKGROUND: The role of clinicopathologic characteristics of the recurrent tumor in determining survival in a cohort of patients with ipsilateral breast tumor recurrence (IBTR) was investigated. METHODS: Among 6020 women with pT1‐T2, pN0‐1, M0 treated with breast‐conserving surgery from 1989 to 1999, 269 developed isolated IBTR. Ten‐year Kaplan‐Meier breast cancer‐specific survival (BCSS) and overall survival (OS), calculated from date of IBTR, were analyzed according to clinicopathologic characteristics. RESULTS: Factors that were associated with diminished OS and BCSS on univariate analysis were: time to IBTR ≤48 months, lymphovascular invasion positive status, estrogen receptor (ER) negative status, high grade, clinical IBTR detection, biopsy alone, and close/positive margins (all P < .05). On multivariate analysis, time to IBTR ≤48 months (hazard ratio [HR], 1.87, P = .012), lymphovascular invasion positive status (HR, 2.46; P < .001), ER negative status (HR, 2.08; P = .013), high‐grade recurrent disease (HR, 1.88; P = .013), and close/positive margins after surgery for IBTR (HR, 1.94; P = .013) retained significance for prediction of diminished OS. When stratified according to number of adverse prognostic features, 10‐year OS was 70.4% in patients with 1 factor, 35.8% with 2 factors, and 19.9% with 3 or more factors (P < .001). CONCLUSIONS: Time to recurrence ≤48 months, lymphovascular invasion positive status, ER negative status, high‐grade histology, and close/positive margins in association with the recurrent tumor are independent prognostic factors for survival after IBTR. The presence of 2 or more of these features at recurrence is significantly associated with poor OS. These criteria can be used to prognosticate and guide clinical decisions after recurrence. Cancer 2011. © 2010 American Cancer Society. The role of clinicopathologic characteristics of the recurrent tumor in determining survival in a cohort with ipsilateral breast tumor recurrence (IBTR) was investigated. Time to recurrence ≤48 months, lymphovascular invasion positive status, estrogen receptor negative status, high‐grade histology, and close/positive margins independently determined prognosis, with 2 or more of these features at recurrence significantly associated with poor overall survival after IBTR.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.25767
Titel-ID: cdi_proquest_miscellaneous_863901815
Format
–
Schlagworte
Adult
,
Aged
,
Aged, 80 and over
,
Breast Neoplasms - mortality
,
Breast Neoplasms - pathology
,
Breast Neoplasms - surgery
,
Disease-Free Survival
,
Follow-Up Studies
,
high grade
,
Humans
,
ipsilateral breast tumor recurrence
,
lymphovascular invasion
,
Middle Aged
,
Neoplasms, Second Primary - mortality
,
Neoplasms, Second Primary - pathology
,
Prognosis
,
Recurrence
,
Risk
,
survival
,
time to recurrence
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