Details

Autor(en) / Beteiligte

• Serwa, Remigiusz
• Tate, Edward W.

Titel

Activity-Based Profiling for Drug Discovery

Ist Teil von

• Chemistry & biology, 2011-04, Vol.18 (4), p.407-409

Ort / Verlag

United States: Elsevier Ltd

Erscheinungsjahr

2011

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Activity-based protein profiling (ABPP) is emerging as a game-changing tool for drug discovery, target validation, and basic biology. In this issue, Chang et al. (2011) report the ABPP-facilitated discovery of JW480, a highly selective potent and orally bioavailable inhibitor of monoalkylglycerol ether hydrolase KIAA1363 that dramatically impairs in vivo growth of human prostate cancer cell lines.