The Journal of infection, 2011-03, Vol.62 (3), p.193-199
2011
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- Autor(en) / Beteiligte
- Titel
- Effect of immunomodulatory therapies in patients with pandemic influenza A (H1N1) 2009 complicated by pneumonia
- Ist Teil von
- The Journal of infection, 2011-03, Vol.62 (3), p.193-199
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Summary Objective To determine the effect of immunomodulatory therapies on the development of severe disease in hospitalized adults with laboratory-confirmed pandemic influenza A (H1N1) 2009 complicated by pneumonia. Methods Observational, prospective cohort study at thirteen tertiary hospitals in Spain. The use of corticosteroids, macrolides and statins was recorded. The outcome of interest was severe disease, defined as the composite of intensive care unit admission or death after the first day of hospitalization. Results Of the 197 patients with pandemic influenza A (H1N1) 2009 complicated by pneumonia, 68 (34.5%) received some anti-inflammatory therapy since hospital admission (corticosteroids in 37, macrolides in 31 and statins in 12). Severe disease occurred in 29 (14.7%) patients. After adjustment for confounding factors, immunomodulatory therapies as a group were not associated with a lower risk for developing severe disease (odds ratio [OR] 0.64; 95% confidence interval [CI] 0.22–1.86). In a further a priori analysis, corticosteroids, macrolides and statins were included in a multivariate model. None of these therapies was found to be associated with a lower risk for developing severe disease. Conclusions Immunomodulatory therapies use since hospital admission did not prevent the development of severe disease in adults with pandemic influenza A (H1N1) 2009 complicated by pneumonia.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0163-4453eISSN: 1532-2742DOI: 10.1016/j.jinf.2011.01.014Titel-ID: cdi_proquest_miscellaneous_862269600
- Format
- –
- Schlagworte
- Adrenal Cortex Hormones - administration & dosage, Adult, Biological and medical sciences, Critical Care - statistics & numerical data, Female, General aspects, Human viral diseases, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage, Immunologic Factors - administration & dosage, Immunomodulation, Infectious Disease, Infectious diseases, Influenza A Virus, H1N1 Subtype - isolation & purification, Influenza, Human - complications, Influenza, Human - mortality, Influenza, Human - therapy, Influenza, Human - virology, Intensive care unit, Macrolides - administration & dosage, Male, Medical sciences, Middle Aged, Mortality, Pandemic influenza A (H1N1) 2009, Pneumology, Pneumonia, Pneumonia, Bacterial - immunology, Pneumonia, Bacterial - mortality, Pneumonia, Bacterial - therapy, Prospective Studies, Respiratory system : syndromes and miscellaneous diseases, Spain, Survival Analysis, Treatment Outcome, Viral diseases, Viral diseases of the respiratory system and ent viral diseases