Details

Autor(en) / Beteiligte

• Ko, Bor-Sheng
• Chang, Tzu-Ching
• Hsu, Chiun
• Chen, Yao-Chang
• Shen, Tang-Long
• Chen, Shyh-Chang
• Wang, John
• Wu, Kenneth K
• Jan, Yee-Jee
• Liou, Jun-Yang

Titel

Overexpression of 14-3-3ε predicts tumour metastasis and poor survival in hepatocellular carcinoma

Ist Teil von

• Histopathology, 2011-04, Vol.58 (5), p.705-711

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2011

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Ko B‐S, Chang T‐C, Hsu C, Chen Y‐C, Shen T‐L, Chen S‐C, Wang J, Wu K K, Jan Y‐J & Liou J‐Y
(2011) Histopathology58, 705–711
Overexpression of 14‐3‐3ε predicts tumour metastasis and poor survival in hepatocellular carcinoma Aims:  The results of our earlier studies suggested that 14‐3‐3ε is involved in cancer cell survival and growth. However, it is not clear whether 14‐3‐3ε plays a role in tumour metastasis and patient outcome. The aim of this study was to determine whether 14‐3‐3ε is a marker for predicting hepatocellular carcinoma (HCC) metastasis and survival. Methods and results:  One hundred and fourteen patients with tissue‐diagnosed primary HCC were followed for an average of 58.6 months. 14‐3‐3ε in liver tissues was analysed by immunohistochemistry, and quantified by a Quick score system. Correlation of 14‐3‐3ε with patient survival and metastasis was analysed with a Wilcoxon signed rank test, Kaplan–Meier survival curves, and Cox proportional hazard regression. Seventy‐one of 114 patients (62.3%) had a significant increase of 14‐3‐3ε expression in HCC tissues, whereas normal tissues expressed weak or undetectable 14‐3‐3ε. Elevated 14‐3‐3ε expression was significantly associated with shortened overall survival and progression‐free survival. Furthermore, 14‐3‐3ε overexpression increased the risk of metastasis 4.6‐fold. Conclusions:  Overexpression of 14‐3‐3ε in primary HCC tissues predicts a high risk of extrahepatic metastasis and worse survival, and is a potential therapeutic target.