Details

Autor(en) / Beteiligte

• Chourasia, Dipti
• Misra, Asha
• Tripathi, Shweta
• Krishnani, Narendra
• Ghoshal, Uday C.

Titel

Patients with Helicobacter pylori infection have less severe gastroesophageal reflux disease: a study using endoscopy, 24-hour gastric and esophageal pH metry

Ist Teil von

• Indian journal of gastroenterology, 2011-02, Vol.30 (1), p.12-21

Ort / Verlag

India: Springer-Verlag

Erscheinungsjahr

2011

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Background and aim The relationship between gastroesophageal reflux disease (GERD) and Helicobacter pylori is controversial. We evaluated endoscopic, 24-h gastric and esophageal acid profile among patients with GERD in relation to H. pylori, as the latter might alter gastric acid secretion. Methods Patients with GERD ( n  = 123), who were not on acid-suppressive drugs, and had not received anti- H. pylori therapy, underwent gastroduodenoscopy and tests for H. pylori detection. Esophageal manometry, 24-h pH metry, serum pepsinogen-I (PG-I), PG-II and gastrin-17 ELISA were done in all these patients. Univariate and multivariate analyses were performed to assess independent predictors for erosive esophagitis (EE). Results Of 123 patients (mean age 40.5 [13.1] years, 85 [69.1%] men), 59 (47.9%) had H. pylori infection. EE was more common in H. pylori non-infected than infected (49 vs. 32, p  < 0.001). Among patients older than 40 years, absence of H. pylori was associated with lower esophageal pH and longer reflux ( p  = 0.02 and p  < 0.001, respectively). PG-I/PG-II ratio was lower in H. pylori infected subjects ( p  < 0.001). In patients with higher LA grade of esophagitis, elevated PG-I levels and PG-I/PG-II ratio were associated with more acidic stomach ( p  = 0.04 and p  = 0.01, respectively). Multivariate analyses showed low gastrin-17 ( p  = 0.016), higher age ( p  = 0.013), hiatus hernia ( p  = 0.004) and absence of H. pylori ( p  = 0.03) were independent predictors for risk of EE. Conclusion H. pylori infection is associated with less acidic stomach and less severe GERD. Low gastrin-17, higher age, hiatus hernia and absence of H. pylori were the best predictors for EE risk.