Details

Autor(en) / Beteiligte

• Nikolova, Dragomira Nikolaeva
• Doganov, Nikolai
• Dimitrov, Rumen
• Angelov, Krasimir
• Low, Siew-Kee
• Dimova, Ivanka
• Toncheva, Draga
• Nakamura, Yusuke
• Zembutsu, Hitoshi

Titel

Genome-wide gene expression profiles of ovarian carcinoma: Identification of molecular targets for the treatment of ovarian carcinoma

Ist Teil von

• Molecular medicine reports, 2009-05, Vol.2 (3), p.365-384

Ort / Verlag

Greece

Erscheinungsjahr

2009

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• This study aimed to clarify the molecular mechanisms involved in ovarian carcinogenesis, and to identify candidate molecular targets for its diagnosis and treatment. The genome-wide gene expression profiles of 22 epithelial ovarian carcinomas were analyzed with a microarray representing 38,500 genes, in combination with laser microbeam microdissection. A total of 273 commonly up-regulated transcripts and 387 down-regulated transcripts were identified in the ovarian carcinoma samples. Of the 273 up-regulated transcripts, only 87 (31.9%) were previously reported as up-regulated in microarray studies using bulk cancer tissues and normal ovarian tissues for analysis. CHMP4C (chromatin-modifying protein 4C) was frequently overexpressed in ovarian carcinoma tissue, but not expressed in the normal human tissues used as a control. Our data should contribute to an improved understanding of tumorigenesis in ovarian cancer, and aid in the development of diagnostic tumor markers and molecular-targeting therapy for patients with the disease.