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Identification of blood microRNAs associated to Parkinsonǐs disease
Ist Teil von
Journal of biotechnology, 2011-03, Vol.152 (3), p.96-101
Ort / Verlag
Amsterdam: Elsevier
Erscheinungsjahr
2011
Quelle
Elsevier ScienceDirect Journals
Beschreibungen/Notizen
The present study demonstrates that blood samples can be used as a source of miRNA identification associated to Parkinson's disease (PD). A set of six differentially expressed microRNAs were identified. They form two groups according to their expression profile in control, non-treated, early-onset and treated Parkinson's disease subjects. While miR-1, miR-22* and miR-29 expression levels allowed to distinguish non-treated PD from healthy subjects, miR-16-2*, miR-26a2* and miR30a differentiated treated from untreated patients. This study is innovative in contributing to the development of effective PD biomarkers.