Details

Autor(en) / Beteiligte

• Vogelmeier, Claus
• Hederer, Bettina
• Glaab, Thomas
• Schmidt, Hendrik
• Rutten-van Mölken, Maureen P.M.H
• Beeh, Kai M
• Rabe, Klaus F
• Fabbri, Leonardo M

Titel

Tiotropium versus Salmeterol for the Prevention of Exacerbations of COPD

Ist Teil von

• The New England journal of medicine, 2011-03, Vol.364 (12), p.1093-1103

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2011

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• An important goal in the treatment of COPD is the prevention of exacerbations. In this trial, the investigators found that treatment with tiotropium, as compared with salmeterol, prolonged the time to the first exacerbation of COPD and decreased the number of exacerbations. Chronic obstructive pulmonary disease (COPD) is a leading cause of disability and death worldwide. 1 – 3 Exacerbations of COPD indicate instability or worsening of the patient's clinical status and progression of the disease and have been associated with the development of complications, an increased risk of subsequent exacerbations, a worsening of coexisting conditions, reduced health status and physical activity, deterioration of lung function, and an increased risk of death. 4 – 7 The prevention of exacerbations therefore constitutes a major goal of treatment. 1 , 2 Therapy with a long-acting anticholinergic drug or a long-acting β 2 -agonist is recommended as first-line maintenance therapy in . . .