Details

Autor(en) / Beteiligte

• VAN RAMSHORST, Jan
• ANTONI, M. Louisa
• ZWAGINGA, Jaap J
• BOERSMA, Eric
• VAN DER WALL, Ernst E
• SCHALIJ, Martin J
• ATSMA, Douwe E
• BAX, J. J
• BEERES, Saskia L. M. A
• ROES, Stijntje D
• DELGADO, Victoria
• RODRIGO, Sander F
• DE ROOS, Albert
• HOLMAN, Eduard R
• FIBBE, Willem E
• LAMB, Hildo J

Titel

Intramyocardial Bone Marrow―Derived Mononuclear Cell Injection for Chronic Myocardial Ischemia: The Effect on Diastolic Function

Ist Teil von

• Circulation. Cardiovascular imaging, 2011-03, Vol.4 (2), p.122-129

Ort / Verlag

Hagerstown, MD: Lippincott Williams & Wilkins

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• The present substudy of a recently published randomized trial aimed to investigate the effect of intramyocardial bone marrow cell injection on diastolic function in patients with chronic myocardial ischemia. In a total of 50 patients, diastolic function was evaluated before and 3 months after bone marrow cell injection using standard echocardiography and strain analysis. In addition, MRI-derived transmitral flow measurements were obtained in a subset of 36 patients. Left ventricular ejection fraction increased from 50±5% to 54±7% in the bone marrow cell group, which was a significant improvement as compared with the placebo group (52±5% versus 51±7%, P=0.001). Filling pressure estimate E/E' ratio improved from 14±5 at baseline to 12±4 at 3 months in the bone marrow cell group, whereas no improvement was observed in the placebo group (13±4 versus 13±5). The improvement in E/E' ratio was significantly larger in the bone marrow cell group (P=0.008). Furthermore, the E/A peak flow ratio as assessed by MRI showed a significant increase in the bone marrow cell group as compared with the placebo group (+0.16±0.25 versus -0.04±0.21, P=0.01), which was mainly related to an increase in the early (E) peak flow rate in the bone marrow cell group (from 407±96 mL/s to 468±110 mL/s, P=0.009 as compared with the placebo group). The current study demonstrates that intramyocardial bone marrow cell injection is associated with a beneficial effect on myocardial relaxation and filling pressures in patients with chronic myocardial ischemia.