Details

Autor(en) / Beteiligte

• WITTKAMPF, FRED H.
• VAN DRIEL, VINCENT J.
• VAN WESSEL, HARRY
• VINK, ARYAN
• HOF, IRENE E.
• GRÜNDEMAN, PAUL F.
• HAUER, RICHARD NW
• LOH, PETER

Titel

Feasibility of Electroporation for the Creation of Pulmonary Vein Ostial Lesions

Ist Teil von

• Journal of cardiovascular electrophysiology, 2011-03, Vol.22 (3), p.302-309

Ort / Verlag

Malden, USA: Blackwell Publishing Inc

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• Feasibility of Electroporation. Introduction: There is an obvious need for a better energy source for pulmonary vein (PV) antrum isolation. Objective: We investigated the feasibility and safety of electroporation for the creation of PV ostial lesions. Methods: After transseptal puncture, a custom 7F decapolar 20 mm circular ablation catheter was placed in the PV ostia of 10 pigs. Ablation was performed with a nonarcing, 200 J application delivered between the catheter and an indifferent patch electrode on the lower back. A single pulse was applied for each catheter position, with a maximum of 4 per ostium. Local PV electrogram amplitude and stimulation threshold were measured at multiple locations in both ostia before and directly after ablation, and after 3 weeks survival, using a regular 4 mm mapping catheter. All PV ostia were sectioned, stained, and histologically investigated. Results: The 3‐week survival period was uneventful. PV ostial electrogram amplitude decreased and stimulation threshold increased significantly in most ostia. PV angiograms did not show any stenosis during this short follow‐up. Histologically, up to 3.5‐mm‐deep lesions were found. Conclusion: Data suggest that electroporation can safely be used to create lesions in a sensitive environment like PV ostia. (J Cardiovasc Electrophysiol, Vol. 22, pp. 302‐309, March 2011)