Details

Autor(en) / Beteiligte

• Provencher, Sawyna
• Ferlay, Céline
• Alaoui-Slimani, Khaoula
• Devidas, Alain
• Lepretre, Stephane
• de Prijck, Bernard
• Sebban, Catherine
• de la Fouchardiere, Arnaud
• Chassagne-Clement, Catherine
• Ketterer, Nicolas
• Thyss, Antoine
• Delannoy, André
• Tilly, Hervé
• Biron, Pierre
• Blay, Jean-Yves
• Ghesquières, Hervé

Titel

Clinical characteristics and outcome of isolated extracerebral relapses of primary central nervous system lymphoma: a case series

Ist Teil von

• Hematological oncology, 2011-03, Vol.29 (1), p.10-16

Ort / Verlag

Chichester, UK: John Wiley & Sons, Ltd

Erscheinungsjahr

2011

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• There is very limited data on isolated systemic relapses of primary central nervous system lymphomas (PCNSL). We retrospectively reviewed the clinical characteristics and outcome of 10 patients with isolated systemic disease among 209 patients with PCNSL mainly treated with methotrexate‐based chemotherapy (CT) with or without radiation therapy (RT). Isolated systemic relapse remained rare (4.8%, 10/209 patients). Median time from initial diagnosis to relapse was 33 months (range, 3–94). Sites of relapse were mostly extranodal. Three patients presented with early extra‐cerebral (EC) relapse 3, 5 and 8 months from the beginning of initial treatment, respectively, and 7 patients had later relapses (range, 17–94 months). Treatment at relapse included surgery alone, RT alone, CT with or without radiotherapy, or CT with autologous stem cell transplantation (ASCT). Median overall survival (OS) after relapse was 15.5 months (range, 5.8–24.5) compared to 4.6 months (range, 3.6–6.5) for patients with central nervous system (CNS) relapse (p = 0.35). In conclusion, isolated systemic relapses exist but are infrequent. Early EC relapse suggests the presence of systemic disease undetectable by conventional evaluation at initial diagnosis. Patient follow‐up must be prolonged because systemic relapse can occur as late as 10 years after initial diagnosis. Whether EC relapses of PCNSL have a better prognosis than CNS relapses needs to be assessed in a larger cohort. Copyright © 2010 John Wiley & Sons, Ltd.