Colloids and surfaces, B, Biointerfaces, 2011-02, Vol.82 (2), p.297-301
2011
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Details
- Autor(en) / Beteiligte
- Titel
- Synthesis, characterization and cytotoxicity studies of chitosan-coated tea polyphenols nanoparticles
- Ist Teil von
- Colloids and surfaces, B, Biointerfaces, 2011-02, Vol.82 (2), p.297-301
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2011
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Chitosan nanoparticles (CS-NPs) were prepared by ionic gelation method using carboxymethyl chitosan and chitosan hydrochloride as carriers of tea polyphenols. The characteristics of chitosan-coated tea polyphenols nanoparticles (CS-TP NPs) were determined by using transmission electron microscopy (TEM) and FT-IR spectroscopy. It was found that the synthesized CS-TP NPs were non-spherical in shape with an average size of 407 ± 50 nm. Meanwhile, the drug content and encapsulation rate of the nanoparticles was 8–16% and 44–83%, respectively. These CS-TP NPs also demonstrated sustained release of tea polyphenols in PBS. The antitumor of CS-TP NPs towards HepG2 cancer cells was investigated. The result showed that CS-TP NPs retained significant antitumor activities.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0927-7765eISSN: 1873-4367DOI: 10.1016/j.colsurfb.2010.08.045Titel-ID: cdi_proquest_miscellaneous_855695491
- Format
- –
- Schlagworte
- anticarcinogenic activity, Carboxymethyl chitosan, Chitosan, Chitosan - analogs & derivatives, Chitosan - chemistry, Chitosan hydrochloride, Chlorides - chemistry, coatings, Cytotoxicity, drugs, Encapsulation, Flavonoids - chemistry, Fourier transform infrared spectroscopy, gelation, Hep G2 Cells, Humans, Ions, Light, Microscopy, Electron, Transmission - methods, Nanoparticles, Nanoparticles - chemistry, Nanotechnology - methods, Phenols - chemistry, Polyphenols, Scattering, Radiation, Spectroscopy, Spectroscopy, Fourier Transform Infrared - methods, Sustained release, Synthesis, Tea, Tea polyphenols, Tetrazolium Salts - pharmacology, Thiazoles - pharmacology, Transmission electron microscopy