Occupational and environmental medicine (London, England), 2011-01, Vol.68 (1), p.64-68
2011
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- Autor(en) / Beteiligte
- Titel
- Long-term air pollution exposure and risk factors for cardiovascular diseases among the elderly in Taiwan
- Ist Teil von
- Occupational and environmental medicine (London, England), 2011-01, Vol.68 (1), p.64-68
- Ort / Verlag
- London: BMJ Publishing Group Ltd
- Erscheinungsjahr
- 2011
- Quelle
- BMJ Journals Archiv - DFG Nationallizenzen
- Beschreibungen/Notizen
- ObjectivesTo investigate changes in blood pressure, blood lipids, blood sugar and haematological markers of inflammation associated with changes in long-term exposure to ambient air pollutants.MethodsWe conducted secondary analyses of data on blood pressure and blood biochemistry markers from the Social Environment and Biomarkers of Aging Study in Taiwan and air pollution data from the Taiwan Environmental Protection Administration in 2000. Associations of 1-year averaged criteria air pollutants (particulate matter with aerodynamic diameters <10 μm (PM10) and <2.5 μm (PM2.5), ozone (O3), nitrogen dioxide (NO2), sulfur dioxide and carbon monoxide) with systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, high-density lipoprotein cholesterol, fasting glucose, haemoglobin A1c (HbA1c), interleukin 6 (IL-6) and neutrophils were explored by applying generalised additive models.ResultsAfter controlling for potential confounders, we observed that increased 1-year averaged particulate air pollutants (PM10 and PM2.5) and NO2 were associated with elevated blood pressure, total cholesterol, fasting glucose, HbA1c, IL-6 and neutrophils. Associations of increased 1-year averaged O3 with elevated blood pressure, total cholesterol, fasting glucose, HbA1c and neutrophils were also observed. In particular, our two-pollutant models showed that PM2.5 was more significantly associated with end-point variables than two gaseous pollutants, O3 and NO2.ConclusionsChanges in blood pressure, blood lipids, blood sugar and haematological markers of inflammation are associated with long-term exposure to ambient air pollutants. This might provide a link between air pollution and atherosclerotic cardiovascular diseases.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1351-0711eISSN: 1470-7926DOI: 10.1136/oem.2009.052704Titel-ID: cdi_proquest_miscellaneous_855676866
- Format
- –
- Schlagworte
- Aged, Aged, 80 and over, Air, Air pollutants, Air pollution, Air Pollution - adverse effects, Air Pollution - analysis, Atherosclerosis, Atherosclerosis (general aspects, experimental research), Biochemistry, Biological and medical sciences, Biomarkers, Biomarkers - blood, Blood, Blood and lymphatic vessels, Blood Glucose - metabolism, Blood lipids, Blood pressure, Blood Pressure - physiology, blood sugar, Body mass index, Carbon monoxide, Cardiology. Vascular system, cardiovascular, Cardiovascular diseases, Cardiovascular Diseases - epidemiology, Cardiovascular Diseases - etiology, Cholesterol, Cholesterols, Cohort analysis, Cytokines, Environment, Environment. Living conditions, Environmental Exposure - adverse effects, Environmental Exposure - analysis, Environmental Monitoring - methods, Environmental pollutants toxicology, Environmental protection, Epidemiological Monitoring, epidemiology, Fasting, Female, Glucose, Health Surveys, Hematology, Hemoglobin, Humans, Hypertension, Inflammation, Inflammation Mediators - blood, Laboratories, Lipids, Lipids - blood, Long-term air pollution, Male, Medical sciences, Middle Aged, Mortality, Neutrophils, Nitrogen dioxide, Older people, Outdoor air quality, Particulate matter, Particulate Matter - analysis, Particulate Matter - toxicity, PM10-PM2.5-ultrafine, Pollutants, public health, Public health. Hygiene, Public health. Hygiene-occupational medicine, Risk Factors, Sugar, Sulfur, Sulfur dioxide, Taiwan - epidemiology, Time Factors, Toxicology, Triglycerides