Details

Autor(en) / Beteiligte

• McDonald, Douglas R., MD, PhD
• Goldman, Frederick, MD
• Gomez-Duarte, Oscar D., MD, PhD
• Issekutz, Andrew C., MD
• Kumararatne, Dinakantha S., MD
• Doffinger, Rainer, PhD
• Geha, Raif S., MD

Titel

Impaired T-cell receptor activation in IL-1 receptor–associated kinase-4–deficient patients

Ist Teil von

• Journal of allergy and clinical immunology, 2010-08, Vol.126 (2), p.332-337.e2

Ort / Verlag

United States: Mosby, Inc

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Background IL-1 receptor–associated kinase 4 (IRAK-4) is an effector of the Toll-like receptor and IL-1 receptor pathways that plays a critical role in innate immune responses. The role of IRAK-4 in adaptive immune functions in human subjects is incompletely understood. Objective We sought to evaluate T-cell function in IRAK-4 deficient patients. Methods We compared upregulation of CD25 and CD69 on T cells and production of IL-2, IL-6, and IFN-γ after stimulation of PBMCs from 4 IRAK-4–deficient patients and healthy control subjects with anti-CD3 and anti-CD28. Results Upregulation of CD25 and CD69 on T cells and production of IL-6 and IFN-γ, but not IL-2, was significantly reduced in IRAK-4–deficient patients. Conclusions IRAK-4–deficient patients have defects in T-cell activation.