Details

Autor(en) / Beteiligte

• Grüber, Christoph, MD, PhD
• van Stuijvenberg, Margriet, MD, MPH
• Mosca, Fabio, MD, PhD, NICU
• Moro, Guido, MD, PhD
• Chirico, Gaetano, MD, PhD
• Braegger, Christian P., MD
• Riedler, Josef, MD, PhD
• Boehm, Günther, MD, PhD
• Wahn, Ulrich, MD, PhD

Titel

Reduced occurrence of early atopic dermatitis because of immunoactive prebiotics among low-atopy-risk infants

Ist Teil von

• Journal of allergy and clinical immunology, 2010-10, Vol.126 (4), p.791-797

Ort / Verlag

New York, NY: Mosby, Inc

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Most infants developing atopic dermatitis have a low risk for atopy. Primary prevention of atopic dermatitis is difficult. Objective To assess the effect of supplementation of an infant and follow-on formula with prebiotic and immunoactive oligosaccharides on the occurrence of atopic dermatitis in the first year of life. Methods Healthy term infants from 5 European countries with low atopy risk were recruited before the age of 8 weeks, either having started with formula feeding or being on full breast-feeding (breast-feeding group). Formula-fed infants were randomized to feeding with a regular formula containing a specific mixture of neutral oligosaccharides and pectin-derived acidic oligosaccharides (prebiotic formula group) or regular formula without oligosaccharides (control formula group). Results A total of 414 infants were randomized to the prebiotic group and 416 infants to the control group. A total of 300 infants were followed in the breast-feeding group. Up to the first birthday, atopic dermatitis occurred in significantly fewer infants from the prebiotic group (5.7%) than from the control group (9.7%; P  = .04). The cumulative incidence of atopic dermatitis in the prebiotic group was in the low range of the breast-feeding group (7.3%). In a Cox regression model, the rate of atopic dermatitis was significantly lower by 44% in the prebiotic group versus the control group ( P  = .04). The number needed to prevent 1 case of atopic dermatitis by supplementation of prebiotics was 25 infants. Conclusion Formula supplementation with a specific mixture of oligosaccharides was effective as primary prevention of atopic dermatitis in low atopy risk infants.