Details

Autor(en) / Beteiligte

• de Andrade, Everaldo Nery
• Gonçalves, Gleisy Kelly Neves
• de Oliveira, Thiago Henrique Caldeira
• Santos, Caroline Silva dos
• Souza, Clarissa Leal Silva e
• Firmes, Luciana Barbosa
• de Magalhães, Amélia Cristina Mendes
• Soares, Telma de Jesus
• Reis, Adelina Martha dos
• Belo, Najara de Oliveira

Titel

Natriuretic peptide system: A link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats

Ist Teil von

• Regulatory peptides, 2011-02, Vol.167 (1), p.149-155

Ort / Verlag

Kidlington: Elsevier B.V

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• The present study was designed to develop an animal model of hypertension and cardiac hypertrophy associated with obesity in female rats. Furthermore, we studied the involvement of the natriuretic peptide system in the mechanisms of these conditions. Obesity was induced in Wistar rats by a high fat diet and ovariectomy. The rats were divided into four groups: ovariectomized or sham-operated with high-fat diet and ovariectomized or sham-operated with control diet. After 24weeks of diet, rats were killed, and their tissues were removed. Cardiac atrial natriuretic peptide (ANP), clearance receptor (NPr-C) gene expression was determined by PCR. ANP concentrations were measured in plasma. Ovariectomized fat-fed rats (OF) showed increased body weight, visceral fat depot and blood pressure and decreased sodium excretion compared to other groups. Also, these rats showed higher heart-to-body weight and cell diameters of ventricular cardiomyocytes and lower cardiac ANP mRNA and plasma ANP than the control group. The adipocyte and renal NPr-C mRNA of OF rats were higher than the control group. These data showed that combined ovariectomy and high fat diet elicited obesity, hypertension and cardiac hypertrophy. These results suggest that the impairment of the natriuretic peptide system may be one of the mechanisms involved not only in development of hypertension but also in cardiac hypertrophy associated with obesity in ovariectomized rats. ► Fat diet and ovariectomy promotes increased fat mass and decreased ANP synthesis. ► Increased fat mass leads to increased clearance receptor expression. ► Clearance receptor reduces plasma ANP levels. ► Reduced plasma ANP levels contributes to hypertension and cardiac hypertrophy.